Renanda B. D. S. Putra, Asus M. S. Hertika, M. Fadjar, Sony Wicaksono, Gaza Algazali Hakim, Febriyansyah Saputra
In this research, acute toxicity (LC50) of cinnamaldehyde and its effect on hematology profile, as well as gill histology, in zebrafish were conducted. Briefly, 4-5 cm zebrafish were exposed to the following cinnamaldehyde concentrations: 0; 1.8; 2.4; 3.2; 4.2; 6.5; or 8.7 ppm for 96 hours. The results showed that cinnamaldehyde affected the hematology of zebrafish by increasing significantly the micronuclei and blood glucose at a concentration of 8,7 ppm (21 cells/mm3 and 193 mg/dL, respectively). Interestingly, the total leukocyte and the phagocytosis increased significantly at the concentration of 4.2 ppm of cinnamaldehyde.. Furthermore, cinnamaldehyde promotes edema, and hyperplasia in the gill structure tissue was observed at the concentrations 4.2, 6.5, and 8.7 ppm with total damage around 1%, 11%, and 45%, respectively. Cinnamaldehyde has acute toxicity LC50 at concentration 7.2 ppm and up to that certain concentration promotes tissue health in the aquatic organism. © 2022, Egyptian Society for the Development of Fisheries and Human Health. All rights reserved.
Department of Aquaculture, Faculty of Fisheries and Marine Sciences, Universitas Brawijaya, Jl. Veteran, East Java, Malang City, Indonesia; Department of Aquatic Resource Management, Faculty of Fisheries and Marine Sciences, Universitas of Brawijaya, Jl. Veteran, East Java, Malang City, Indonesia; Rayon Mitra Merdeka, Jl. Raya Permata Suci No. 49,PPS, Manyar, East Java, Gresik, Indonesia
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