Anthony Christanto, Ngakan Putu Parsama Putra, Christian Surya Eka Putra
Bronchoscopy, essential for respiratory diagnosis and treatment, carries a risk of post-procedural bleeding, especially in procedures like transbronchial lung biopsies (TBLB). This review evaluates tranexamic acid (TXA) for managing post-procedural bleeding in bronchoscopy. TXA is a synthetic lysine analog that inhibits plasminogen activation and promotes clot stability, therefore preventing and reducing bleeding. Evidence suggests that both topical and systemic administration can effectively reduce the incidence and severity of post-bronchoscopy bleeding. While generally well tolerated, considerations for TXA use include patient selection and awareness of potential risks, such as thromboembolic events. Further research is needed to establish optimal dosing regimens, administration routes, and long-term safety profiles to fully integrate TXA into bronchoscopy practice. © 2026 Indian Chest Society.
Department of Pulmonology and Respiratory Medicine, Brawijaya University Hospital, East Java, Malang, Indonesia; Department of Pulmonology and Respiratory Medicine, Division of Pulmonary Intervention, Brawijaya University, Malang, Indonesia
