Entin Srihadi Yanti, Rasyidah Rasyidah, Bambang Rahardjo, Rahajeng, Husnul Khotimah, Dwi Yuni Nur Hidayati
Preeclampsia is a clinical syndrome characterized by proteinuria and hypertension after 20 weeks of pregnancy. Pathophysiology of preeclampsia is affected by an imbalance of systemic angiogenic factors and immunological factors. TGF-β can represent a proangiogenic factor in preeclampsia and IL-10 is one of the anti-inflammatory cytokines found to be low in preeclampsia conditions. Pravastatin is an antihyperlipidemic drug candidate for a potential therapy for preeclampsia. This study aims to determine the effect of pravastatin on TGF-β and IL-10 serum levels in the preeclampsia rat model. It used five groups consisting of negative control (normal pregnant rats) group, positive control (preeclampsia rat model induced L-NAME 125 mg/Kg BW) group, preeclampsia rat model groups given pravastatin in 3 different doses (2 mg/day, 4 mg/day, and 8 mg/day). On days 12, 15, and 19, the blood pressure of pregnant rats was measured. The serum was collected after the rats were sacrificed in order to determine TGF-β and IL-10 levels. The result showed an increase in TGF-β serum level (p=0.003) and IL-10 serum level (p=0.001). Therefore, pravastatin can increase TGF-β and IL-10 levels significantly in preeclampsia rat models. © 2023 American Institute of Physics Inc.. All rights reserved.
Department of Midwifery, Faculty of Medicine, Universitas Brawijaya, Jalan Veteran, Jawa Timur, Malang, 65145, Indonesia; Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Brawijaya, Saiful Anwar General Hospital, Jalan Veteran, Jawa Timur, Malang, 65145, Indonesia; Department of Biomedicine, Faculty of Medicine, Universitas Brawijaya, Jawa Timur, Malang, 65145, Indonesia; Department of Microbiology, Faculty of Medicine, Universitas Brawijaya, Jawa Timur, Malang, 65145, Indonesia
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