Putu Ijiya Danta Awatara, Levrita Nindya Poetri, Jonny Karunia Fajar, Syifa Mustika
Studies have assessed that the liver enzymes were proven having the association with insulin resistance (IR) in patients with liver disease; however, there were conflicting findings across the reports. The purpose of this study was to assess the association between liver enzymes and Homeostatic Model Assessment Insulin Resistance (HOMA-IR) in patients with non-alcoholic fatty liver disease (NAFLD). We conducted a meta-analysis between April 2022 and August 2022. Data were obtained from articles in PubMed, ScienceDirect, Cochrane Library, and Taylor & Francis. Using a Z test, the liver enzymes and the HOMA-IR among patients with NALD were compared. We included 683 patients with elevated liver enzymes and 3.579 patients with normal liver enzymes, retrieved from five papers. HOMA-IR score appeared higher in patients with NAFLD with elevated alanine aminotransferase (ALT) than in patients with normal ALT [ALT, mean difference (MD): 1.02; 95% confidence interval (CI): 0.49, 1.54]. Conversely, the aspartate aminotransferase (AST), alkaline phosphatase (ALP), and gamma-glutamyl transferase (GGT) had no crucial impact in affectting the HOMA-IR when compared between patients with NAFLD and control [(AST, MD: 0.81; 95% CI: 0.21, 1.40), (GGT, MD: 0.77; 95% CI: 0.20, 1.34), and (ALP, MD: 0.90; 95% CI: 0.22, 1.57)]. IR assessed using HOMAIR has a significant association with abnormal liver enzymes in patients with NAFLD. © 2023 by Türkiye Klinikleri.
Malang General Hospital, Malang, Indonesia; Army Hospital Doctor Soepraoen, Malang, Indonesia; Department of Internal Medicine, University of Brawijaya, Faculty of Medicine, Malang, Indonesia; Department of Gastroenterohepatology, Doctor Saiful Anwar General Hospital, Malang, Indonesia
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