Ghita Yogisuari, Rocky Fahriar Reza, Lailia Nur Rachma, Tri Yudani Mardining Raras, Antonius Nugraha Widhi Pratama, Ari Satia Nugraha, Bawon Triatmoko
Background: A limited spectrum and inappropriate use of anthelmintics lead to anthelmintic resistance. Among Indonesian medicinal plants, Adiantum raddianum (Suplir) and Kibatalia arborea (Jelutong Pipit) have shown antihelmintic properties. Objective: To reveal the anthelmintic activity as preliminary screening of A. raddianum and K. arborea leaves. Method: This study used the antihelmintic microdilution test towards methanol extracts at 500 µg/mL. The mortality of Caenorhabditis elegans expresses the presence of anthelmintic activity. Phytochemical screening was determined using thin-layer chromatography. Result: The methanol extracts of both extracts had anthelmintic activity with mortality values of 14.941% and 15.134%, respectively. Both extracts contain polyphenols, flavonoids, terpenoids, and alkaloids found only in K. arborea. Conclusion: This study reveals that the methanol extract of A. raddianum and K. arborea leaves have anthelmintic activity, which could be related to the findings of phytochemical constituents. © 2023 FIP.
Drug Utilisation and Discovery Research Group, Faculty of Pharmacy, University of Jember, Jember, Indonesia; UPT Laboratorium Herbal Materia Medica Batu, Malang, Indonesia; Doctoral Program of Medical Science, Universitas Brawijaya, Malang, Indonesia; Department of Microbiology, Faculty of Medical and Health Science, Maulana Malik Ibrahim State Islamic University, Malang, Indonesia; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia
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