R. Mohamad Javier, Stephanie Angela Prijanto, Vallexa Septina Yora, Desak Gede Yuliana Eka Pratiwi, Errini Sabilla Lilhawa Ditsi, Bella Adelia, Verika Christabela Tansuri, Hendry Wijaya, Georaldhy Yussufy Caecarma, Intan Trikumala Damayanti, Anisa Ramadhanti, Atika Rahmaputri, Chabib Fachry Albab, Afif Ferdian, Fatih Farabi, Fadila Risang Ayu, Ni Putu Ika Regina Maharani, Andika Prasetyo Arifin, Eko Setyo Herwanto, Saidah Rahmat A, Safira Dita Arviana, Syifa Nur Lathifah, Nanda Rizki Yulinar, Laksmitha Saktiono Safitri, Basyar Adnani, M. Rizki Fazrian Danu, Natasya Naomi, Dayu Dwi Deria, Aulia Syifa, Panca Andana, Adrian Prasetya, Fachira Rachel Agfata, Magistra Cylvia Margaretha, Subandono Bambang Indrasto, Sukirman, Rachmanto, Hayatun Nufus, Pertiwi Febriana Chandrawati, Aan Dwi Prasetyo, Lucky Sutanto, Moch Aleq Sander
Background: The Monkeypox Virus (MPOX) has caused a surge in viral infections, leading to the WHO recognizing it as a public health emergency of international concern. MPOX infection shares clinical similarities with smallpox but can cause complications like myocarditis, anorectal pain, ocular lesions, kidney damage, or soft tissue superinfection. The study aims to understand the characteristics of myocarditis, fixed drug eruption, and dry eye syndrome in Monkeypox patients. Methods: This review was conducted based on PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses), and the Cochrane Handbook for Systematic Reviews of Interventions. The data was obtained from Scopus and international journal databases by conducting combined keyword searches restricted to English-language publications. Result: The study examined 25 cases of Monkeypox, primarily involving males aged 32.9 years and experiencing chest pain. The prognosis was generally good, with no reported death. Risk factors for infection include sexual activity, STD diagnosis, sexual encounters, and workplace exposure to orthopoxviruses. Most cases were male and involved chest pain. Myocarditis, an inflammation in the myocardium, can cause dilated cardiomyopathy, acute arrhythmia, and heart failure. The pathophysiology of myocarditis in Monkeypox patients is not yet determined due to rarity of cases. Conclusion: MPOX infection presents unique complications like myocarditis, necessitating research for vaccines, antiviral drugs, and infection prevention measures. Early screening for chest pain and investigating MPXV infection's pathogenesis and clinical features are crucial for differential diagnosis during outbreaks. This systematic review can determine MPOX infection outcomes and prepare appropriate treatment for patients with complications. 2025 Mohamad Javier, Prijanto, Yora, Yuliana Eka Pratiwi, Lilhawa Ditsi, Adelia, Tansuri, Wijaya, Caecarma, Damayanti, Ramadhanti, Rahmaputri, Albab, Ferdian, Farabi, Ayu, Ika Regina Maharani, Arifin, Herwanto, A, Arviana, Lathifah, Yulinar, Safitri, Adnani, Fazrian Danu, Naomi, Deria, Syifa, Andana, Prasetya, Agfata, Margaretha, Indrasto, Sukirman, Rachmanto, Nufus, Chandrawati, Prasetyo, Sutanto and Sander.
Department of Internal Medicine, Gatot Soebroto Army Hospital, Jakarta, Indonesia; Faculty of Medicine, Widya Mandala Surabaya Catholic University, Surabaya, Indonesia; Faculty of Medicine, Muhammadiyah Malang University, Malang, Indonesia; Faculty of Medicine, Brawijaya Univeristy, Malang, Indonesia; Faculty of Medicine, Pelita Harapan University, Tangerang, Indonesia; Faculty of Medicine, Atma Jaya Indonesian Catholic University, Jakarta, Indonesia; Faculty of Medicine, Airlangga University, Surabaya, Indonesia; Department of Internal Medicine, Permata Bunda Hospital, Malang, Indonesia; Department of Internal Medicine, Heartology Cardiovascular Hospital, Jakarta, Indonesia; Faculty of Medicine, Diponegoro University, Semarang, Indonesia; Faculty of Medicine, Hang Tuah Surabaya University, Surabaya, Indonesia; Faculty of Medicine, Krida Wacana Christian University, Jakarta, Indonesia; Faculty of Medicine, Maulana Malik Ibrahim Malang University, Malang, Indonesia; Department of Internal Medicine, Bayu Asih Purwakarta Hospital, Purwakarta, Indonesia; Faculty of Medicine, Jember University, Jember, Indonesia; Faculty of Medicine, Malikussaleh University, Aceh, Indonesia; Faculty of Medicine, Islamic University of Indonesia, Yogyakarta, Indonesia; Department of Opthalmology, Gatot Soebroto Army Hospital, Jakarta, Indonesia; Department of Pediatric, Gatot Soebroto Army Hospital, Jakarta, Indonesia; Department of Internal Medicine, Persahabatan Hospital, Jakarta, Indonesia; Department of Pediatric, Muhammadiyah Malang University Hospital, Malang, Indonesia; Department of Neurology, Muhammadiyah Malang University Hospital, Malang, Indonesia; Department of Obstetrics and Gynecology, Kartika Husada Tanjungpura, Tanjungpura, Indonesia; Department of Surgery, Muhammadiyah Malang University Hospital, Malang, Indonesia
