Eka Yudha Rahman, Nia Kania, Hendra Sutapa, Athaya Febriantyo Purnomo, Roselina Panghiyangani, Nika Sterina Skripsiana
Background: Prostate cancer remains a significant global health concern, necessitat-ing the exploration of novel therapeutic avenues to enhance treatment efficacy and mit-igate adverse effects. Objective This study delves into the potential anticancer proper-ties of Pasak Bumi (Eurycoma longifolia Jack) root extract, a traditional Southeast Asian medicinal plant, against prostate cancer. Methods: The research employs a multifaceted approach, encompassing molecular and cellular analyses to unravel the intricate mechanisms underlying Pasak Bumi's effects on prostate cancer cells. Primary focus is given to the PTEN/P13k/Akt pathway, a critical regulator of cell survival and apoptosis. Various concentrations of Pasak Bumi root extract are applied to prostate cancer cell lines, and the impact on apoptosis, cell proliferation, and key molecular targets is assessed. Results: Preliminary findings reveal that Pasak Bumi root extract induces apoptosis in prostate cancer cells, evidenced by downstream molecular events associated with programmed cell death. The extract demonstrates concentration-dependent effects, with higher concentrations exhibiting more pronounced anticancer activity. Moreover, Pasak Bumi root extract appears to modulate the PTEN/P13k/Akt pathway, providing a potential mechanistic link to its anticancer effects. Discussion: The study's significance lies in its contribution to the evolving landscape of natural compounds as anticancer agents, particularly in the context of prostate cancer. Pasak Bumi's traditional use as a medicinal plant, coupled with emerg-ing scientific evidence, underscores its potential translational value. The observed mod-ulation of the PTEN/P13k/Akt pathway aligns with the current understanding of prostate cancer pathogenesis, offering a plausible explanation for Pasak Bumi's anticancer effects. Conclusion: This research sheds light on the promising anticancer potential of Pasak Bumi root extract against prostate cancer. Further exploration of its molecular interactions, syn-ergy with conventional therapies, and efficacy at different stages of cancer progression is warranted. The findings present Pasak Bumi as a nature-inspired candidate for prostate cancer treatment, warranting continued investigation into its therapeutic applications. As the scientific community endeavors to enhance cancer treatment modalities, Pasak Bumi emerges as a captivating subject in the pursuit of effective and minimally invasive prostate cancer therapies. © 2024 Eka Yudha Rahman, Nia Kania, Hendra Sutapa, Athaya Febriantyo Purnomo, Roselina Panghiyangani, Nika Sterina Skripsiana.
Department of Urology Surgery, Faculty of Medicine, Universitas Lambung Mangkurat, Ulin General Hospital, South Borneo, Banjarmasin, Indonesia; Department of Pathology Anatomy, Faculty of Medicine, Universitas Lambung Mangkurat, Ulin General Hospital, South Borneo, Banjarmasin, Indonesia; Department of Urology, Faculty of Medicine, Universitas Brawijaya, Saiful Anwar General Hospital, East Java, Malang, Indonesia; Department of Oncology, Medical Sciences Division, University of Oxford, Oxford, OX3 7DQ, United Kingdom; Department of Biomedic, Faculty of Medicine, Universitas Lambung Mangkurat, Ulin General Hospital, South Borneo, Banjarmasin, Indonesia; Faculty of Medicine, Universitas Lambung Mangkurat, South Borneo, Banjarmasin, Indonesia; Department of Public Health Sciences, Faculty of Medicine, Universitas Lambung Mangkurat, South Borneo, Banjarmasin, Indonesia
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