Bobby Indra Utama, Arif Bima Al Birru, Kevin Nathaniel Cuandra, Ratna Puspita, Stevan Arianto, Galih Yudo Pranowo, Qanita Saifana, Made Aditya Krisnanta Gandhy, Karisya Juwita Puteri, Rafhy Mifindra, Gabriela Valencia Putri Husodho, Rio Fernando Alexander, Meda Yuliani, Boenga NurCita, Christopher Daniel Tristan
Background – Stress urinary incontinence (SUI) is a prevalent pelvic floor disorder with significant effects on women’s quality of life. While surgical and non-surgical interventions exist, limitations underscore the need for alternative therapies. Injectable platelet-rich plasma (PRP) has emerged as a regenerative approach targeting tissue restoration. This study aimed to systematically evaluate the efficacy and safety of PRP injections for female SUI. Methods – This systematic review and meta-analysis adhered to the PRISMA guidelines. Comprehensive searches of PubMed, Scopus, and Cochrane Library up to April 2025 identified randomized controlled trials (RCTs) and quasi-experimental studies assessing PRP for SUI. The review protocol was prospectively registered in the International Prospective Register of Systematic Reviews (CRD420251118485). Eligible studies reported outcomes on symptom severity, urodynamic parameters, quality of life, or adverse events. Risk of bias was assessed using Cochrane RoB 2.0 for RCTs and the NHLBI tool for before–and–after studies. Pooled effect sizes were calculated using random- or fixed-effects models as appropriate. Results – Eight studies (three RCTs and five quasi-experimental; n = 257) were included. PRP significantly improved symptom severity, with pooled reductions in UDI-6 and ICIQ-SF scores at 1–3 months. Urodynamic analysis revealed significant increases in abdominal leak point pressure (MD = 51.07; 95% CI: 36.21–65.93; p < 0.0001), while functional profile length remained unchanged. Quality-of-life scores (IIQ-7, ICIQ-SF) showed consistent improvement. Reported adverse events were mild and self-limiting, with no serious complications observed. Conclusion – Injectable PRP demonstrates promising short-term efficacy in reducing symptoms, improving urodynamic function, and enhancing quality of life in women with SUI, with a favorable safety profile. Larger, standardized RCTs with longer follow-up are needed to validate durability and define its role relative to established therapies. Systematic review registration – CRD420251118485. Copyright © 2026 Utama, Birru, Cuandra, Puspita, Arianto, Pranowo, Saifana, Gandhy, Puteri, Mifindra, Husodho, Alexander, Yuliani, NurCita and Tristan.
Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Andalas, Padang, Indonesia; Department of Medicine, Faculty of Medicine, Universitas Andalas, Padang, Indonesia; Department of Biochemistry, Faculty of Medicine, Universitas Pembangunan Nasional Veteran Jakarta, Jakarta, Indonesia; Department of Medical Laboratory Technology, Institut Kesehatan Hermina, Jakarta, Indonesia; Department of Medicine, Faculty of Medicine, Universitas Muhammadiyah Yogyakarta, Yogyakarta, Indonesia; Department of Medicine, Faculty of Medicine, Universitas Yarsi, Jakarta, Indonesia; Department of Medicine, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogya-karta, Indonesia; Department of Medicine, Faculty of Medicine, Universitas Brawijaya, East Java, Indonesia; Department of Medicine, Faculty of Medicine, Universitas Diponegoro, Central Java, Indonesia; Department of Fiscal Administration Science, Faculty of Administrative Sciences, Universitas Indonesia, Jakarta, Indonesia; Department of Midwifery, Faculty of Health Sciences, Universitas Bhakti Kencana Bandung, Bandung, Indonesia; Department of Histology, Faculty of Medicine, Universitas Pembangunan Nasional Veteran Jakarta, Jakarta, Indonesia; Department of Medicine, Faculty of Medicine, Universitas Sebelas Maret, Central Java, Indonesia
