Fiki M. Ridho, Areindra P. Wicaksana, Ridwan Alfatah, Siska M. Cahyani, Alfi Syahri, Jufriady Ismy
This study aims to determine the association between periodontal disease (PD) and prostate cancer (PC) using systematic review and meta-analysis. Any observational studies investigating the association between PD and PC published in PubMed, Scopus, ScienceDirect, and Google Scholar from inception to 2024 were reviewed. The Newcastle-Ottawa Scale was used to assess study quality. Stata version 17.0 software was used for all statistical analyses. The study’s findings were reported as odds ratios (ORs) with 95% confidence intervals (CIs) through fixed-or random-effects model meta-analysis. Nine studies involving 621,982 male participants aged ≥ 20 years were finally included in this meta-analysis. The fixed-effects model meta-analysis revealed a significant association between PD and PC (OR = 1.19; 95% CI = 1.12-1.28; p = 0.0000). The present meta-analysis was robust based on the results of sensitivity analysis. This meta-analysis demonstrates a significant association between PD and PC, potentially driven by chronic inflammation and migration of periodontal pathogenic bacterial. © 2025 Sociedad Colombiana de Urología. Publicado por Permanyer.
Department of Dental Medicine, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia; Department of Nursing, Faculty of Health Sciences, Universitas Aisyiyah Yogyakarta, Yogyakarta, Indonesia; Department of Medicine, Faculty of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia; Department of Dental Surgery, Faculty of Dental Medicine, Universitas Brawijaya, Malang, Indonesia; Department of Surgical Medical Nursing, Faculty of Nursing, Universitas Airlangga, Surabaya, Indonesia; Department of Nursing, Doctoral Program, Faculty of Nursing, Universitas Airlangga, Surabaya, Indonesia; Department of Advanced Nursing, Faculty of Nursing, Institut Kesehatan Deli Husada, Deli Serdang, Indonesia; Department of Urology, Faculty of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia; Division of Urology, Department of Surgery, Dr. Zainoel Abidin Hospital, Banca Aceh, Indonesia
