Erlan Anugrah Pratama, Lirasati Sadikaningtya, Malik Jantra Indarto, Andi Wahyono Adi, Bambang Budi Siswanto
Background: The relationship between periodontitis and venous thromboembolism (VTE) remains controversial. Some studies show an association, while others do not show an association between periodontitis and VTE. Objectives: This study aims to determine the relationship between periodontitis and the risk of VTE using a meta-analysis approach. Methods: A meta-analysis study, registered in PROSPERO, was conducted from August to September 2024. The sources for article searches in this study were Scopus, Embase, and PubMed. Data on the proportion of VTE occurrences in the periodontitis and non-periodontitis groups were collected from each article, and pooled point estimates were calculated using the Mantel-Haenszel test. Results: We identified 40,397 VTE cases and 2,215,063 controls from six articles. Among these six articles, three showed an association between periodontitis and an increased risk of VTE. Additionally, we identified one article reporting that periodontitis was associated with a decreased risk of VTE. Furthermore, two articles revealed that periodontitis had no association with VTE occurrence. Our calculations using the Mantel-Haenszel test showed that, overall, an increased risk of VTE was found in individuals with periodontitis compared to those without (RR: 1.61; 95% CI: 1.09 – 2.39; Egger's p: 0.7917; Heterogeneity p: <0.0001; p: 0.0200). Conclusion: We have identified that periodontitis is an important factor in the occurrence of VTE. © 2025, Brawijaya University. All rights reserved.
Department of Emergency, Aisyiyah Islamic Hospital, Malang, Indonesia; Department of Dentistry, Klinik Pratama Palang Merah Indonesia, Malang, Indonesia; Pancoran Primary Healthcare, Jakarta, Indonesia; Department of Cardiology and Vascular Medicine, Brawijaya University Hospital, Malang, Indonesia; Department of Cardiology and Vascular Medicine, Aisyiyah Islamic Hospital, Malang, Indonesia; Department of Cardiology and Vascular Medicine, National Cardiovascular Center Harapan Kita Hospital, Jakarta, Indonesia
