Derren Rampengan, Stevanus Surya, Diski Saisa, Jade Rampengan, Roy Ramadhan, Albert Pratama, Ammar Nojaid, Ika Kadariswantiningsih, Starry Rampengan, Maulana Empitu
Background: The development of eHealth has offered a solution to the challenge of effective self-management for patients with heart failure (HF) by facilitating health information exchange, enabling frequent home monitoring, enhancing self-management and promoting patient empowerment. This study aimed to evaluate the effectiveness of eHealth interventions in improving self-management for patients with HF. Methods: Systematic review and meta-analysis were performed adhering to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) reporting guidelines, by first selecting the relevant publications from the Cochrane Library, EBSCOhost, Epistemonikos, ProQuest, PubMed and Scopus as of 25 February 2025. The quality of the included studies was appraised using Cochrane Risk of Bias 2.0 tool. A meta-analysis of randomized controlled trials was performed using Review Manager software to estimate odds ratios (ORs) and standardized mean differences (SMDs). Results: We included 37 trials with 13,366 participants. eHealth reduced HF-related admissions (OR: 0.73 [95% confidence interval (CI): 0.62, 0.86; p=0.0002]). All-cause mortality did not differ (OR: 0.93 [95% CI: 0.85, 1.03; p=0.16]). Cardiovascular mortality was not reduced (OR: 0.85 [95% CI: 0.71, 1.01; p=0.07]). Quality of life showed borderline improvement on the Minnesota total score (mean difference:-7.25 [95% CI:-14.81, 0.31; p=0.06]; I²=91%). HF-related knowledge did not differ (SMD: 0.53 [95% CI:-0.12, 1.19; p=0.11]). Conclusion: This meta-analysis demonstrates that incorporating eHealth interventions, particularly telemedicine, into standard HF care substantially decreases hospital admissions. While broader impacts on mortality, quality of life and knowledge remain inconclusive, the findings underscore the value of standardized eHealth integration as a pragmatic strategy to strengthen HF management and optimize patient outcomes. © 2025, Touch Medical Media. All rights reserved.
Medical Doctor Program, Faculty of Medicine, Universitas Sam Ratulangi-Prof Dr RD Kandou Central General Hospital, North Sulawesi, Manado, Indonesia; Medical Doctor Program, Faculty of Medicine, Universitas Udayana-Prof Dr IGNG Ngoerah Central General Hospital, Bali, Kota Denpasar, Indonesia; Medical Doctor Program, Faculty of Medicine, Universitas Indonesia-Dr Cipto Mangunkusumo National General Hospital, Java, Jakarta, Indonesia; Medical Doctor Program, Faculty of Medicine, Atma Jaya Catholic University of Indonesia-R Syamsudin, SH Regional General Hospital, Java, Sukabumi, Indonesia; Medical Doctor Program, Faculty of Medicine, Airlangga University-Dr Soetomo Regional General Hospital, Java, Surabaya, Indonesia; Medical Doctor Program, Faculty of Medicine, Universitas Brawijaya-Saiful Anwar Regional General Hospital, Java, Malang, Indonesia; Translational Medicine Research Group, Faculty of Medicine, Airlangga University, East Java, Surabaya, Indonesia; Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Sam Ratulangi, North Sulawesi, Manado, Indonesia; Department of Cardiology and Vascular Medicine, RD Kandou Central General Hospital, North Sulawesi, Manado, Indonesia; Department of Pharmacology, Faculty of Medicine, Airlangga University, East Java, Surabaya, Indonesia; Department of Medicine, Faculty of Health, Medicine, and Life Sciences (FIKKIA), Airlangga University, East Java, Banyuwangi, Indonesia
