Sofy Permana, Neyla Vista Maramy, Maghfira Rahma Azizah, Halida Adib Hanum, Yoshiyuki Kawamoto, Edwin Widodo, Heni Endrawati, Agustina Tri Endharti
Triple negative breast cancer (TNBC) lacks ER, PR, and HER2 expression, leading to poor prognosis. Tectona grandis contains bioactive compounds with anticancer properties. This study investigated antiproliferative and antimigratory effect of T. grandis leaves extract (TGLE) and paclitaxel. This study involved computational study to determine the binding affinity of Mucin-1 and TGLE and in vitro study to examine the antiproliferative and antimigratory effect of TGLE and paclitaxel as well as the Mucin 1 (MUC1) and Matrix Metalloproteinase-9 (MMP9) expression in MDA-MB-231 cells. This study identified quercetin in TGLE as the strongest compound to bind with MUC1. In vitro study confirmed the inhibitory effect of TGLE and paclitaxel on MUC1 expression and cell proliferation. Furthermore, TGLE and paclitaxel exhibited a significant reduction in MMP-9 expression and cell migration. These findings suggest that TGLE and paclitaxel has promising antiproliferative and antimigratory properties against TNBC through its inhibition on MUC1 and MMP-9. © 2026, Walailak University. All rights reserved.
Department of Biology, Faculty of Mathematic and Natural Sciences, Universitas Brawijaya, East Java, Indonesia; Universitas Brawijaya, Post Doctoral Fellow, East Java, Indonesia; Medical Professional Study Program, Faculty of Medicine, Brawijaya University, East Java, Indonesia; Department of Biomedical Sciences, Graduate School of Life and Health Sciences, Chubu University, Aichi, Japan; Department of Physiology, Faculty of Medicine, Universitas Brawijaya, East Java, Indonesia; Departement of Parasitology, Faculty of Medicine, Universitas Brawijaya, East Java, Indonesia; Innovation Center of Integrative Jamu and Eco-pharmaca, Universitas Brawijaya, East Java, Indonesia; Immunotherapy Research Group, Faculty of Medicine, Universitas Brawijaya, East Java, Indonesia
