Leony Octavia, Dwi Andhika Panjarwanto, Putri Nabila, Putri Lenggo Geany, R. Mohamad Javier, Aldo Aulia Rahman, Vallexa Septina Yora, Lucky Sutanto, Arthur Peter Tandayu, Srigita Varsha, Sofyan Solichin
Background: Polycystic Ovary Syndrome (PCOS) is a common endocrine disorder affecting reproductive-age women and is often associated with infertility challenges. Recent studies suggest that vitamin D levels play a significant role in reproductive outcomes, particularly in PCOS patients undergoing in vitro fertilization (IVF). Methods: A systematic review was conducted following PRISMA guidelines. Studies published between 2014 and 2024 were analyzed, focusing on the impact of pre-treatment vitamin D levels on IVF outcomes such as fertilization rates, implantation rates, clinical pregnancy, and live birth rates. Only studies on PCOS-related infertility were included, while non-PCOS infertility cases were excluded. Result: The review examined 59 studies, highlighting variations in outcomes based on study design and populations. Evidence generally supports the hypothesis that adequate vitamin D levels are associated with improved IVF success, though inconsistencies remain. Further research is recommended to standardize supplementation protocols and better understand vitamin D’s biological mechanisms in reproductive health. Conclusion: The relationship between initial vitamin D levels and in vitro fertilization (IVF) outcomes in women with polycystic ovary syndrome (PCOS) suggests that vitamin D plays a crucial role in enhancing IVF success, although the findings remain somewhat inconsistent. Research generally points to a positive correlation between higher baseline vitamin D levels and improved reproductive results, including increased live birth rates, pregnancy rates, and better ovarian responses during IVF treatments. Systematic review registration: CRD42024622381, https://www.crd.york.ac.uk/PROSPERO/view/CRD42024622381. Copyright © 2025 Octavia, Andhika Panjarwanto, Nabila, Geany, Javier, Rahman, Yora, Sutanto, Tandayu, Varsha and Solichin.
Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Faculty of Medicine, Brawijaya University, Malang, Indonesia; Faculty of Medicine, Pelita Harapan University, Tangerang, Indonesia; Faculty of Medicine, Diponegoro University, Semarang, Indonesia; Department of Cardiology and Vascular, RS University of Indonesia, Depok, Indonesia; Faculty of Medicine, Sriwijaya University, Palembang, Indonesia; Faculty of Medicine, Muhammadiyah Malang University, Malang, Indonesia; Military Hospital of the Indonesian Army Kartika Husada, Tanjungpura, Indonesia; Faculty of Medicine, Padjadjaran University, Bandung, Indonesia
