Novita G. Liman, Sunu B. Raharjo, Ina Susianti Timan, Franciscus D. Suyatna, Salim Harris, Joedo Prihartono, Kristiana Siste, Mohammad Saifur Rohman, Bambang Budi Siswanto
Background and Objective. Premature ventricular complex (PVC) burden exhibits one of three circadian types, classified as fast-type, slow-type, and independent-type PVC. It is unknown whether PVC circadian types have different heart rate variability (HRV) parameter values. Therefore, this study aimed to evaluate differences in HRV circadian rhythm among fast-, slow-, and independent-type PVC. Methods. This cross-sectional observational study consecutively recruited 65 idiopathic PVC subjects (23 fast-, 20 slow-, and 22 independent-type) as well as five control subjects. Each subject underwent a 24-hour Holter to examine PVC burden and HRV. HRV analysis included components that primarily reflect global, parasympathetic, and sympathetic activities. Repeated measures analysis of variance was used to compare differences in HRV circadian rhythm by PVC type. Results. The average PVC burden was 15.7%, 8.4%, and 13.6% in fast-, slow-, and independent-type idiopathic PVC subjects, respectively. Global, parasympathetic nervous system, and sympathetic nervous system HRV parameters were significantly lower in independent-type PVC versus fast- and slow-type PVC throughout the day and night. Furthermore, we unexpectedly found that tendency towards sympathetic activity dominance during nighttime was only in independent-type PVC. Conclusion. The HRV parameters are reduced in patients with independent-type PVC compared to fast- and slow-type PVC. Future research is warranted to determine possible differences in the prognosis between the three PVC types. © The Author(s) 2025.
Doctoral Program in Medical Sciences, Faculty of Medicine, Universitas Indonesia, Indonesia; Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, Indonesia; Human Genetic Research Center, Indonesia Medical Education and Research Institute, Universitas Indonesia, Indonesia; Department of Clinical Pharmacology, Faculty of Medicine, Universitas Indonesia, Indonesia; Department of Neurology, Faculty of Medicine, Universitas Indonesia, Indonesia; Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Indonesia; Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Indonesia; Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Brawijaya, Indonesia; Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jl. Letjend S. Parman Kav 87, Slipi, Jakarta, 11420, Indonesia
