Luailik Madaniyah, Saidun Fiddaroini, Elok Kamilah Hayati, Moh. Farid Rahman, Akhmad Sabarudin
This work investigates the anticancer potential of silver nanoparticles (AgNPs) against T47D cells as well as the stability of AgNPs manufactured using extract from Acalypha indica L. used as a bioreductant. The plant extract was used to produce and stabilize AgNPs, and stability was tracked for 30 days using UV-Vis spectroscopy and Particle Size Analysis (PSA), which included evaluations of extended sun exposure. Transmission Electron Microscopy (TEM) was used to characterize the size and shape of the nanoparticles, and Fourier Transform-Infrared Spectroscopy (FT-IR) was used to determine which functional groups were responsible for stabilization. Despite a gradual size increase, the AgNPs remained stable throughout the study period. The MTT assay confirmed their potent cytotoxicity against T47D cells, underscoring the potential of Acalypha indica-derived AgNPs as stable and effective agents for cancer therapy, offering a promising alternative for novel anticancer treatments. © 2025 The Authors.
Department of Chemistry, Faculty of Science, Brawijaya University, Malang, 65145, Indonesia; Chemistry Study Program, Faculty of Science and Technology, Maulana Malik Ibrahim Islamic State University, Malang, 65144, Indonesia; Research Center for Advanced System and Material Technology, Brawijaya University, Malang, 65145, Indonesia
