Hermin Sulistyarti, Aina Jefelina Nuur, Anggita Cahyaningrum, Rurini Retnowati, Akhmad Sabarudin, Muhammad Mashuri Utama, Petr Solich
The vital role of aluminum in the pharmaceutical industry and pharmaceutical products is unquestioned, as it is extensively used in antacid formulation, antiperspirants, and adjuvants for vaccinations. However, it should be noted that above the tolerable intake, aluminum can cause harmful effects on health, primarily affecting the nervous system, Alzheimer’s disease, and breast cancer. This study aims to develop a new green flow injection (FI) spectrophotometry for aluminum determination based on the complex formation between Al3+ and anthocyanins in red galangal flower extract, forming a complex purple solution detected at a maximum wavelength of 555 nm. The optimum performance of the method was achieved under the conditions of pH 6, 3% (v/v) extract dilution from the concentrated extract, 125 cm mixing coil, and 150 µl sample volume. This method was selective against Pb2+, Mg2+, and Ca2+ interfering metal ions up to 100 mg l-1 with error values < 5%. This new method has been successfully applied to determine Al3+ in antiperspirant and antacid tablets with high accuracy (95–100% recovery) and satisfactory precision (RSD < 5%) with a high analysis rate of up to 100 samples/h. © (2025), (Iranian Chemical Society). All rights reserved.
Department of Chemistry, Faculty of Mathematics and Natural Science, Brawijaya University, Malang, 65145, Indonesia; LCAMIA (Low Cost and Automated Method and Instrumentation Analysis) Research Group, Brawijaya University, Malang, 65145, Indonesia; Department of Analytical Chemistry, Faculty of Pharmacy, Charles University, Hradec Kralove, 500 03, Czech Republic
Research at a Glance
Register to unlock
Topics & SDG Alignment
Register to unlock
Collaboration
Register to unlock
Author Profile (Selected)
Register to unlock
References Overview
Register to unlock
Journal & Source
Register to unlock
Metadata & Integrity
Register to unlock