Isngadi Isngadi, Aswoco A. Asmoro, Nurul Huda, Taufiq A. Siswagama, Nancy M. Rehatta, Susilo Chandra, Djayanti Sari, Mayang I. Lestari, Tjokorda G. A. Senapathi, Haizah Nurdin, Belindo Wirabuana, Bintang Pramodana, Adinda P. Pradhana, Novita Anggraeni, Kenanga M. Sikumbang, Radian A. Halimi, Zafrullah K. Jasa, Akhyar H. Nasution, Mochamat Mochamat, Purwoko Purwoko
Background: Changes in cognitive function are associated with increased depression and decreased quality of life (QOL). This study aimed to determine the relationship between the characteristics of geriatric patients and anesthetic management with changes in postoperative cognitive function and QOL of geriatric patients undergoing elective surgery. Methods: This prospective observational analytic multicenter study included patients aged ≥60 years who underwent elective surgery in hospitals in Indonesia. We used the whole sampling method and performed follow-up 30 days after surgery. Data were analyzed using bivariate chi-square and multivariate regression tests with a confidence interval of 95% and α=5%. Results: Among the 933 geriatric patients included in this study (55.0%, females), most (59.8%) received general anesthesia. Factors including age (p<0.001, B=-0.374, odds ratio [OR]=0.688), body mass index (BMI) (p<0.05, B=0.129, OR=1.138), and physical status based on American Society of Anesthesiologists (ASA) classifica-tion (p<0.001, B=-0.458, OR=0.633) were significantly associated with postoperative cognitive function. BMI (p<0.001, B=-0.218, OR=1.244), absence of comorbidities (p<0.05, B=-0.312, OR=0.732), regional anesthesia (p<0.05, B=0.606, OR=1.883), and changes in cognitive function (p<0.05, B=0.288, OR=1.334) were significantly correlated with changes in postoperative QOL. Conclusion: Age, BMI, and ASA physical status were significantly associated with postoperative cognitive function in geriatric patients, whereas BMI, comorbidities, regional anesthesia, and changes in postoperative cognitive function were associated with QOL. These preoperative factors can predict postoperative cognitive function and QOL and may be useful during preoperative planning. © 2025 by The Korean Geriatrics Society.
Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, Brawijaya University–Dr. Saiful Anwar General Hospital, Malang, Indonesia; Department of Anesthesiology and Reanimation, Faculty of Medicine, Airlangga University–Dr. Soetomo General Hospital, Surabaya, Indonesia; Department of Anesthesiology and Intensive Care, Faculty of Medicine, University of Indonesia–Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, Public Health, and Nursing, Gadjah Mada University–Dr. Sardjito General Hospital, Yogyakarta, Indonesia; Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, Sriwijaya University–Dr. Mohammed Hoesin General Hospital, Palembang, Indonesia; Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, Udayana University–Sanglah General Hospital, Denpasar, Indonesia; Department of Anesthesiology and Intensive Care, Faculty of Medicine, Hasanuddin University–Dr. Wahidin Sudirohusodo General Hospital, Makassar, Indonesia; Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, Riau University–Arifin Achmad General Hospital, Riau, Indonesia; Department of Anesthesiology and Intensive Care, Faculty of Medicine, Lambung Mangkurat University–Ulin General Hospital, Banjarmasin, Indonesia; Department of Anesthesiology and Intensive Care, Faculty of Medicine, Padjadjaran University–Dr. Hasan Sadikin General Hospital, Bandung, Indonesia; Anesthesiology and Intensive Therapy Department, Faculty of Medicine, Syiah Kuala University/ Dr. Zainoel Abidin General Hospital, Banda Aceh, Indonesia; Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, Universitas Sumatera Utara–Dr. Adam Malik General Hospital, Medan, Indonesia; Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, Diponegoro University–Dr. Kariadi General Hospital, Semarang, Indonesia; Department of Anesthesiology and Intensive Care, Faculty of Medicine, Sebelas Maret University Dr. Moewardi General Hospital, Surakarta, Indonesia
