Zamroni Afif, Dheka Sapti Iskandar, Annisatul Hakimah, Syafiatul Azizah, Nurvia Andriani, Kartika Agustina, Shahdevi Nandar Kurniawan, Husnul Khotimah, Irawan Satriotomo
Insomnia is inability to maintain or elevate sleep quality at least three times a day, more than three days in a week, or more than three months. One of theories that is explaining insomnia causes focuses on a condition called hyperarousal, which is related to increasing mental, cognitive, and motor activities. This study was applied to create the insomnia model, that zebrafish larvae were exposed to illumination with intensity of 200 lux. There were four phases of light exposure, consist of 12 hours of light with 12 hours of dark, and 18 hours of light with 6 hours of flash. The flash phase group was divided into two groups consist of 2 minutes light on with 2 minutes dark and 4 minutes light on with 1 minute dark. The result showed that the 24-hour treatment, both light and dark cycles, have a lower inactive frequency and a higher distance moved compared to the control group. © 2025 American Institute of Physics Inc.. All rights reserved.
Doctoral Program, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Master Program Biomedical Sciences, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Residency Program, Department of Neurology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Department of Neurology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Departement of Pharmacology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Indonesian Neuroscience Institute, Jakarta, Indonesia
