Iriana Maharani, Loeki Enggar Fitri, Susanthy Djajalaksana, Edi Handoko, Yudha Adi Pradana
Introduction: Chronic rhinosinusitis (CRS) is classified into CRS with nasal polyps (CRSwNP), a type 2 inflammation with elevated CLC and ECP levels, and CRS without nasal polyps (CRSsNP), a non-type 2 inflammation. Periostin plays a crucial role in mucosal remodeling, but its involvement in CRSwNP remains unclear. Aims/objectives: To investigate correlation between CRSwNP endotype and periostin levels. Materials and methods: This cross-sectional study measured endotype biomarkers (ECP, CLC, IFN-γ, IL-17A) and periostin levels in uncinate process and nasal polyps using ELISA to assess their correlation. Results: 99.6% of uncinate process and 36.67% of nasal polyp tissue samples displayed a mixed endotype pattern, while 2 samples were untype-able. Periostin levels were significantly higher in nasal polyp compared to uncinate process tissue (p =.0116) and control. Only ECP levels in the uncinate process showed a significant correlation with periostin (r = 0.326, p =.038). Conclusion and significance: Periostin is significantly elevated in nasal polyps, highlighting its role in CRSwNP. Its correlation with ECP in the uncinate process suggests involvement in inflammation, warranting further research into periostin as a therapeutic target. This study confirms periostin’s role in CRSwNP, it potentially occurs with or without depending on the CRS endotype pathways. © 2025 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
Doctoral Program in Medical Science, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Brawijaya, Dr. Saiful Anwar General Hospital, Malang, Indonesia; Department of Clinical Parasitology, Faculty of Medicine, Universitas Brawijaya, Dr. Saiful Anwar General Hospital, Malang, Indonesia; Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Brawijaya, Dr. Saiful Anwar General Hospital, East Java, Indonesia
