Wiwi Jaya, Hani Susianti, Sumarno Reto Prawiro, Aswoco Andyk Asmoro, Reza Ariestyawan Ramadhan, Muhammad Rezha Mansyur, Numbi Akhmadi Teguh
Vitamin D deficiency is prevalent in critical illness and linked to poor outcomes. This study investigated the relationship between vitamin D supplementation, Sequential Organ Failure Assessment (SOFA) scores, and clinical outcomes in septic ICU patients. In a longitudinal observational design, 30 vitamin D-deficient adults (SOFA ≥2) were divided into control (standard care, *n*=15) and intervention (single 400,000 IU vitamin D₃ dose, *n*=15) groups. Serum 25(OH)D and SOFA scores were measured at baseline (Day 1) and Day 7. Outcomes included mortality/discharge rates. Statistical analyses employed independent *t*-tests, Chi-square, and Pearson correlation. Despite comparable gender distribution, the intervention group was significantly younger (49.13 ± 19.96 vs. 62.93 ± 13.69 years; *p*=0.036). Post-intervention, vitamin D levels increased markedly in the treatment group (9.27 ± 5.79 ng/mL vs. control: 7.43 ± 5.58 ng/mL; *p*=0.32), while SOFA scores were significantly higher (7.93 ± 1.48 vs. 5.93 ± 1.48; *p*=0.001). The intervention group showed clinically meaningful but non-significant improvements: lower mortality (40.0% vs. 73.3%; *p*=0.065) and higher discharge rates (60.0% vs. 26.7%). A negative correlation between Δvitamin D and ΔSOFA suggested reduced organ dysfunction with rising vitamin D. High-dose vitamin D supplementation may improve survival and discharge rates in critically ill patients despite higher baseline organ dysfunction. Age disparities and small sample size limit definitive conclusions, but findings support further investigation in larger trials. © 2026 by SPC (Sami Publishing Company).
Doctoral Program in Medical Sciences, Faculty of Medicine, Universitas Brawijaya, Malang, 65145, Indonesia; Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, Universitas Brawijaya, Malang, 65145, Indonesia; Dr. Saiful Anwar General Hospital, Malang, 65111, Indonesia; Faculty of Medicine, Universitas Brawijaya, Malang, 65145, Indonesia; Department of Microbiology, Faculty of Medicine, Universitas Brawijaya, Malang, 65415, Indonesia; Specialist Program in Anesthesiology and Intensive Therapy, Faculty of Medicine, Universitas Brawijaya, Malang, 65145, Indonesia
