Kobajashi Togo Isamu, Eddy Suprayitno, Yahya, Anies Chamidah, Aulanni’am, Muhammad Fikri Nur, Rihma Fathin Fataty, Fajriah, Ansharullah, Agus Dwi Ananto
Hypertension is a major global health concern that significantly increases the risk of cardiovascular diseases, stroke, and kidney failure. The search for antihypertensive agents from natural sources has gained increasing attention due to their potential efficacy and minimal side effects. Among these, bioactive peptides derived from marine and freshwater organisms have shown strong angiotensin-converting enzyme (ACE) inhibitory activity, making them promising candidates for hypertension treatment. This study investigated the potential of peptides derived from Batissa violacea as ACE inhibitors using an in silico approach. Molecular docking was conducted to assess the binding affinity and interactions of selected peptides with the ACE active site. Additionally, ADMET predictions were performed to evaluate the physicochemical and pharmacokinetic properties of the most promising peptide sequences. The results identified three peptides—SVDLVIFSLH, RPSAKKLLRT, and TMFIWCIVVT—with the lowest binding energies, indicating strong and stable interactions with ACE. These findings suggest that the peptides may effectively inhibit ACE activity and contribute to blood pressure regulation. Furthermore, ADMET analysis revealed that the candidate peptides exhibit an extended half-life and do not pose mutagenic or significant arrhythmic risks. To enhance their therapeutic potential, injectable formulations, dose adjustments, and stabilization strategies such as PEGylation or liposomal delivery are recommended. Overall, this study highlights the potential of Batissa violacea-derived peptides as natural antihypertensive agents and provides valuable insights into the development of peptide-based therapies for hypertension management. © 2025, Egyptian Society for the Development of Fisheries and Human Health. All rights reserved.
Faculty of Fisheries and Marine Science, Brawijaya University, East Java, Malang, Indonesia; Department of Fisheries Product Technology, Faculty of Fisheries and Marine Science, Halu Oleo University, Southeast Sulawesi, Kendari, Indonesia; Department of Fisheries Product Technology, Faculty of Fisheries and Marine Science, Brawijaya University, East Java, Malang, Indonesia; Biochemistry Laboratory, Faculty of Mathematics and Natural Sciences, Brawijaya University, East Java, Malang, Indonesia; Department of Fisheries Resource Utilization, Faculty of Fisheries and Marine Science, Muhammadiyah University of Kendari, Southeast Sulawesi, Kendari, Indonesia; Department of Food Technology, Faculty of Agriculture, Halu Oleo University, Southeast Sulawesi, Kendari, Indonesia; Department of Pharmacy, Faculty of Medicine and Health Sciences, Universitas Mataram, Mataram, Indonesia
