H. Kristianto, E.P.L. Fatma, R.T. Ariningpraja, F.A. Rihastara, M.S.A. Mishbahriyah, A.A.P. Giantari, S.M. Hapsari, A.P. Prameswari
The study investigates the potential of Karsen leaves (Muntingia calabura L.) extract in spray gel form to aid the healing of second-degree burns. This experimental research assesses the effects of the extract on key inflammatory and proliferative indicators: wound temperature, erythema, skin moisture and wound contraction. Rats with induced burns were treated with varying concentrations (12.5%, 15% and 17.5%) of the extract over 14 days. Results demonstrated that the 15% concentration effectively managed wound base temperature and enhanced wound contraction, while the 17.5% concentration significantly re-duced erythema and retained skin moisture in the proliferative phase. These findings suggest that Karsen leaves extract in spray gel form has promising therapeutic benefits for burn wound healing. Further research could enhance formulation efficacy and expand its clinical applications. © 2025, Mediterranean Club for Burns and Fire Disasters. All rights reserved.
School of Nursing, Faculty of Health Science, Universitas Brawijaya, Malang, Indonesia; Metabolic Syndrome Research Group, Faculty of Health Science Universitas Brawijaya, Malang, Indonesia; Wound and Foot Clinic, Academic Hospital, Universitas Brawijaya, Malang, Indonesia
