Fiki Muhammad. Ridho, R. Alfatah, S.M. Cahyani, V.A. Tasyah, R.S. Rahmawati
INTRODUCTION: The present study was conducted to evaluate the association between periodontitis and sperm quality. METHODS: A systematic review and meta-analysis of any observational studies published from inception to August 2 024 i n Scopus, PubMed, ScienceDirect, EBSCO, a nd Google Scholar was performed. AJBI checklist was used to assess the risk of bias. Statistical analysis was performed using Stata version 17. Fixed-or random-effects model meta-analyses were used and reported as pooled odds ratio (OR) and 95% confidence interval (CI). RESULTS: Six studies involving 987 men aged ≥21 years were included in the systematic review, and four of them were included in the meta-analysis. Periodontitis was significantly associated with any sperm abnormalities (OR = 1.86; 95% CI = 1.32-2.60; p = 0.0003). In subgroup analysis, significant associations were found between periodontitis and sperm quality in Asian populations (OR = 2.13; 95% CI = 1.48-3.07; p = 0.0001) and subnormal sperm count (OR = 2.08; 95% CI = 1.03-4.23; p = 0.04). When stratified by the severity, moderate-to-severe periodontitis was associated with sperm quality (OR = 2.76; 95% CI = 1.78-4.26; p <0.0001). CONCLUSION: This study shows that periodontitis is associated with any sperm abnormalities. © The Author(s).
Department of Dental Medicine, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, 60132, Indonesia; Faculty of Medicine, Universitas Islam Negeri Walisongo, Semarang, 50185, Indonesia; Dental Surgery, Faculty of Dental Medicine, Universitas Brawijaya, Malang, 65145, Indonesia; Department of Medicine, Faculty of Medicine and Health Sciences, Universitas Bengkulu, Bengkulu, 38119, Indonesia; Department of Periodontology, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, 60132, Indonesia
