Danung Nur Adli, Cecep Hidayat, Ridho Kurniawan Rusli, Rantan Krisnan, Endang Romjali, Arif Darmawan, Bachtar Bakrie, Santiananda Arta Asmarasari, Simon Petrus Ginting, Supardi Rusdiana, Lisa Praharani, Andi Tarigan, Ali Husni
This study aimed to investigate the effects of zinc nanoparticles (Zn NPs) on broiler chickens through a meta-analytical approach. A total of 125 scientific articles were initially screened via databases such as Scopus, Web of Science, PubMed Central, and Google Scholar, with “Zinc NPs” and “broiler chickens” as the main keywords. Following rigorous selection criteria, 25 articles were deemed eligible for inclusion. The data were processed via the PROC MIXED procedure in SAS 9.3.2 to evaluate various parameters, including growth performance, carcass characteristics, nutrient digestibility, hematological profiles, immune markers, and antioxidant activity. Zn NP supplementation significantly increased the concentrations of IgG and the serum antioxidant enzymes AST and ALT, with optimal doses of 40.89 mg/kg and 71.41 mg/kg, respectively. However, supplementation also led to reduced ether extract digestibility, diminished zinc levels in liver and bone tissue, and lowered red blood cell counts while increasing white blood cell counts. No significant changes were observed in the other parameters. Although Zn NPs offer benefits in terms of immune and antioxidant enhancement, they also pose drawbacks, particularly in terms of nutrient absorption and zinc retention. The recommended dosage ranges to balance these outcomes is 40.89–71.41 mg/kg. © The Author(s), under exclusive licence to Springer Nature B.V. 2025.
Feed and Animal Nutrition Department, Faculty of Animal Science, Smart Livestock Industry Study Programme, Universitas Brawijaya, Malang, Indonesia; World’s Poultry Science Association Indonesian Branch, Bogor-West Java, Indonesia; Research Center for Animal Husbandry, Research Organisation for Agriculture and Food, Cibinong Science Centre, National Research and Innovation Agency of Indonesia, Jalan Raya Jakarta-Bogor, Cibinong, West Java, Bogor, 16915, Indonesia; Department of Nutrition and Feed Technology, Faculty of Animal Science, Universitas Andalas, Padang, 25175, Indonesia; Department of Animal Nutrition and Feed Technology, Faculty of Animal Science, IPB University, Bogor, 16680, Indonesia
