Muhaimin Rifa'i, Yoshiyuki Kawamoto, Izumi Nakashima, Haruhiko Suzuki
Regulation of immune system is of paramount importance to prevent immune attacks, against self-components. Mice deficient in the interleukin (IL)-2/IL-15 receptor β chain, CD122, are model animals of such immune attacks and characteristically have a high number of abnormally activated T cells. Here, we show that the transfer of CD8+CD122+ cells into CD122-deficient neonates totally prevented the development of abnormal T cells. Furthermore, recombination activating gene-2-/- mice that received wild-type mice-derived CD8+CD122- cells died within 10 wk after cell transfer, indicating that normal CD8+CD122- cells become dangerously activated T cells in the absence of CD 8+CD122÷ T cells. CD8+CD122+ cells could control activated CD8+ or CD4+ T cells both in vivo and in vitro. Our results indicate that the CD8+CD122 + population includes naturally occurring CD8+ regulatory T cells that control potentially dangerous T cells.
Department of Immunology, Nagoya Univ. Grad. Sch. of Medicine, Nagoya 466-8550, Japan; Brawijaya University, Malang 65145, East Java, Indonesia; Dept. of Immunology, Nagoya Univ. Grad. Sch. of Medicine, Showa-ku, Nagoya 466-8550, 65 Tsurumai-cho, Japan
