Rebecca L. Prowse, Nicola Dalbeth, Arthur Kavanaugh, Adewale O. Adebajo, Angelo L. Gaffo, Robert Terkeltaub, Brian F. Mandell, Bagus P.P. Suryana, Claudia Goldenstein-Schainberg, Cèsar Diaz-Torne, Dinesh Khanna, Frederic Lioté, Geraldine McCarthy, Gail S. Kerr, Hisashi Yamanaka, Hein Janssens, Herbert F. Baraf, Jiunn-Horng Chen, Janitzia Vazquez-Mellado, Leslie R. Harrold, Lisa K. Stamp, Mart A. Van De Laar, Matthijs Janssen, Michael Doherty, Maarten Boers, N. Lawrence Edwards, Peter Gow, Peter Chapman, Puja Khanna, Philip S. Helliwell, Rebecca Grainger, H. Ralph Schumacher, Tuhina Neogi, Tim L. Jansen, Worawit Louthrenoo, Francisca Sivera, William J. Taylor
Objective. To identify a comprehensive list of features that might discriminate between gout and other rheumatic musculoskeletal conditions, to be used subsequently for a case-control study to develop and test new classification criteria for gout. Methods. Two Delphi exercises were conducted using Web-based questionnaires: one with physicians from several countries who had an interest in gout and one with patients from New Zealand who had gout. Physicians rated a list of potentially discriminating features that were identified by literature review and expert opinion, and patients rated a list of features that they generated themselves. Agreement was defined by the RAND/UCLA disagreement index. Results. Forty-four experienced physicians and 9 patients responded to all iterations. For physicians, 71 items were identified by literature review and 15 more were suggested by physicians. The physician survey showed agreement for 26 discriminatory features and 15 as not discriminatory. The patients identified 46 features of gout, for which there was agreement on 25 items as being discriminatory and 7 items as not discriminatory. Conclusion. Patients and physicians agreed upon several key features of gout. Physicians emphasized objective findings, imaging, and patterns of symptoms, whereas patients emphasized severity, functional results, and idiographic perception of symptoms. The Journal of Rheumatology Copyright © 2013. All rights reserved.
University of Otago, Dunedin, New Zealand; University of Auckland, Auckland, New Zealand; Veterans Affairs Healthcare System, University of California, San Diego, CA, United States; University of Sheffield, Sheffield, United Kingdom; Veterans Affairs Medical Center, University of Alabama at Birmingham, Birmingham, AL, United States; CCF Lerner College of Medicine, Case Western Reserve University, Cleveland Clinic, Cleveland, OH, United States; Brawijaya University, Dr. Saiful Anwar Hospital, Malang, Indonesia; Faculdade de Medicina da Universidade de São Paulo, Hospital das Clínicas da Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil; Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; University of Michigan, Ann Arbor, MI, United States; University Paris Diderot, Sorbonne Paris Cité, Hôpital Lariboisière, Paris, France; University College Dublin, Dublin, Ireland; Veterans Affairs Medical Center, Georgetown, Howard Universities, Washington, DC, United States; Tokyo Women's Medical University, Tokyo, Japan; Department of Primary and Community Care, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands; Center for Rheumatology and Bone Research, Arthritis and Rheumatism Associates, Wheaton, MD, United States; China Medical University, China Medical University Hospital, Taichung, Taiwan; Hospital General de Mexico, Mexico City, Mexico; University of Massachusetts Medical School, Worcester, MA, United States; University of Otago, Christchurch, New Zealand; Department of Rheumatology and Clinical Immunology, Medisch Spectrum Twente, Enschede, Netherlands; Department of Rheumatology, Rijnstate, Arnhem, Netherlands; University of Nottingham, Nottingham, United Kingdom; VU University Medical Center, Amsterdam, Netherlands; University of Florida, Gainesville FL, United States; Counties-Manukau District Health Board, Auckland, New Zealand; Canterbury District Health Board, Christchurch, New Zealand; University of Leeds, Leeds, United Kingdom; Department of Medicine, University of Otago Wellington, Wellington 6242, PO Box 7343, New Zealand; University of Pennsylvania, Veterans Affairs Medical Center, Philadelphia, PA, United States; Boston University School of Medicine, Boston, MA, United States; Department of Rheumatology, Radboud University Nijmegen Medisch Centrum, Nijmegen, Netherlands; Chiang Mai University, Chiang Mai, Thailand; Hospital General de Elda, Universidad Miguel Hernandez, Alicante, Spain
