Na-Youn Lee, Hye-Young Min, Jun Lee, Joo-Won Nam, Yoo-Jin Lee, Ah-Reum Han, Adam Wiryawan, Wahyu Suprapto, Sang Kook Lee, Eun-Kyoung Sec
A new biflavanone, 2,2″,3,3″-tetrahydrorobustaflavone 7,4′,7″ trimethyl ether (1) was isolated from the whole plant of Selaginella doederleinii HIERON. (Selaginellaceae) together with the known biflavonoid, robustaflavone 7,4′,7″ trimethyl ether (2) as the cytotoxic constituents against the three human cancer cell lines, HCT, NCI-H358, and K562. The structure of the new compound 1 was elucidated by spectral analysis including various 1D-and 2D NMR experiments. © 2008 Pharmaceutical Society of Japan.
College of Pharmacy, Center for Cell Signaling and Drug Discovery Research, Ewha Womans University, Seoul 120-750, South Korea; Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine, Daejeon 305-812, South Korea; Brawijaya University, Malang 65145, Indonesia; Batu Herba Medica Centre, East Java, Indonesia
