Ahmad Bi Utomo, A. Aulamiam, Yunia Sribudiani, Dwi Agustian, Muhammad Aris Widodo, Basukibambang Purnomo, Tri Hanggono Achmad
Androgen is important in the development of prostate glands and defect in its signaling pathway could induce prostate glands carcinogenesis. The CAG repeat polymorphism on exon 1 of Androgen Receptor (AR) gene and the lipid profile. It have been reported as genetic and environmental risk factors for the development of prostate cancer (PCa). This research aims to investigate the association of CAG repeat of AR, lipid profile and combination of both with clinicopathological features of prostate cancer in Javanese population, Indonesia. We conducted a cross-sectional study of prostate cancerfrom October 2013 to September 2014. Correlation analysis was performed to examine the association between CAG repeat of AR and lipid profile with the tumor grade (PSA level) and tumor stage (Gleason score).We observed that there is no association between cholesterol level with either PSA or Gleason Score. Multivariable analysis showed that level of triglyceride was negatively associated with Gleason Score (β =-0.1054, p = 0. 044) but not with the PSA (β =-2,042, p = 0.270). The CAG repeat is not associated either with the level of PSA (β =-12.611, p = 0.524) or with the Gleason score (β =-0.1056s, p = 0.225). It suggest that there is no association between variability of CAG repeat length and the level of cholesterol with the clinicopathological features. The level of triglyceride is negatively associated with the Gleason score. Although not significant, men with shorter CAG repeat tend to develop PCa earlier than those with longer CAG repeat. © 2015, Sphinx Knowledge House. All rights Reserved.
Department of Urology, Brawijaya University, Malang, Indonesia; Department of Biochemistry and Molecular Biology, Padjadjaran University, Bandung, Indonesia; Department of Epidemiology, Padjadjaran University, Bandung, Indonesia
