Ahmed G. Moh. Jabran, Setyawati Soeharto, Hidayat Sujuti
The aim of this study is to investigate the hepatoprotective effect of ginger extract in different doses against hepatotoxicity caused by carbofuran in male wistar rats from the histological and biochemical aspects. Twenty five male rats were divided into five groups, each representing as A: control negative (normal saline), B: control positive (0.8mg of carbofuran 10%), C: first experimental dose (0.8mg of carbofuran ang 500mg of ginger extract), D: second experimental dose (0.8mg of carbofuran (10%) and 750mg of ginger extract), E: third experimental dose (0.8mg of carbofuran and 1000mg of ginger extract). Study duration was one month. Liver specimen were examined by light microscope and the serum from all groups were examined by spectrophotometry. Resulted in a significant reduction in the levels of alanine aminotransferase (ALT) enzymes in comparison with the carbofuran treated animals; ginger extract also improves the histological changes produced by carbofuran in the liver tissues. The present study indicated that ginger had protective effect against liver damage induced by carbofuran and this is caused by antioxidant activities. © 2015, Sphinx Knowledge House. All right reserved.
Department of Toxicology, Brawijaya University, Malang, Indonesia; Department of Pharmacology, Brawijaya University, Malang, Indonesia; Department of Biochemistry, Brawijaya University, Malang, Indonesia
