Dewi Santosaningsih, Sanarto Santoso, Nyoman S. Budayanti, Kuntaman Kuntaman, Endang S. Lestari, Helmia Farida, Rebriarina Hapsari, Purnomo Hadi, Winarto Winarto, Catarina Milheiriço, Kees Maquelin, Diana Willemse-Erix, Alex Van Belkum, Juliëtte A. Severin, Henri A. Verbrugh
Data of Staphylococcus aureus carriage in Indonesian hospitals are scarce. Therefore, the epidemiology of S. aureus among surgery patients in three academic hospitals in Indonesia was studied. In total, 366 of 1,502 (24.4%) patients carried S. aureus. The methicillin-resistant S. aureus (MRSA) carriage rate was 4.3%, whereas 1.5% of the patients carried Panton-Valentine leukocidin (PVL)-positive methicillin-sensitive S. aureus (MSSA). Semarang and Malang city (odds ratio [OR] 9.4 and OR 9.0), being male (OR 2.4), hospitalization for more than 5 days (OR 11.708), and antibiotic therapy during hospitalization (OR 2.6) were independent determinants for MRSA carriage, whereas prior hospitalization (OR 2.5) was the only one risk factor for PVL-positive MSSA carriage. Typing of MRSA strains by Raman spectroscopy showed three large clusters assigned type 21, 24, and 38, all corresponding to ST239-MRSA-SCCmec type III. In conclusion, MRSA and PVL-positive MSSA are present among patients in surgical wards in Indonesian academic hospitals. Copyright © 2014 by The American Society of Tropical Medicine and Hygiene.
Department of Microbiology, Faculty of Medicine, Brawijaya University, Malang, 65145, Jl. Veteran, Indonesia; Department of Microbiology, Faculty of Medicine, Udayana University/Sanglah Hospital, Denpasar, Bali, Indonesia; Department of Microbiology, Faculty of Medicine, Airlangga University/Dr. Soetomo Hospital, Surabaya, Indonesia; Department of Microbiology, Faculty of Medicine, Diponegoro University/Dr. Kariadi Hospital, Semarang, Indonesia; Laboratory of Molecular Genetics, Instituto de Tecnologia Quimica e Biológica, Universidade Nova de Lisboa, Oeiras, Portugal; Department of Dermatology, Erasmus University Medical Center, Rotterdam, Netherlands; Microbiology Unit, BioMérieux, Inc., La Balme, France; Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center, Rotterdam, Netherlands
