Mustafa Hamed Omar Aljahawey, Setyawati Soeharto, Hidayat Sujuti
To evaluate the protective effects of Zingiber officinalle rosco (Ginger) against carbofuran-induced reproductive toxicity in rats and to study the mechanisms of these effects. Methods: Twenty five male rats were divided into five groups, each representing as A: control negative (normal saline), B: control positive (0.8 mg of carbofuran 10%), C: first experimental dose (0.8 mg of carbofuran and 500 mg of ginger extract), D: second experimental dose (0.8 mg of carbofuran (10%) and 750 mg of ginger extract), E: third experimental dose (0.8 mg of carbofuran and 1000 mg ginger extract). The research was done in one month. Results: Treatments with only carbofuran showed a significant decrease of testosterone and increase in proliferation of leydig cell, while the combination of ginger extract with carbofuran showed a significant increase of testosterone and decrease in proliferation of leydig cell (similar results to that of the control negative group: P>0.05). Conclusion: According to the obtained results, it can conclude that the extract of ginger (Z. Officinale) at 750 mg dose produced counteract effect to the deleterious effect on reproductive parameter (testosterone level, leydig cell histopathology) which produced by carbofuran and it is potential for therapeutic role. © 2015, Sphinx Knowledge House. All right reserved.
Department of toxicology, Brawijaya University, Malang, Indonesia; Department of pharmacology, Brawijaya University, Malang, Indonesia; Department of Biochemistry, Brawijaya University, Malang, Indonesia
