Aswoco Andyk Asmoro, Ramacandra Rakhmatullah, Scarpia Puspitasari, Khairunnisai Tarimah, Siti Chasnak Saleh, Mochammad Aris Widodo, Edi Widjajanto
Objective: To report the effect of ketamine treatment on inflammatory cytokines induced by lipopolysaccharide. Methods: Human umbilical vein endothelial cells culture was used in this research. The measurement of inflammatory cytokines was performed by using ELISA. Results: The results showed various levels of inflammatory cytokines. The nuclear factor-κB results were unstable, but interleukin 6 and tumor necrosis factor-α showed similar results. The expressions of interleukin 6 and tumor necrosis factor-α decreased in all observation times. Conclusions: In general, our results of human umbilical vein endothelial cells culture were supported by other researches related with the effect of ketamine in suppressing inflammatory effect induced by lipopolysaccharide. Ketamine could suppress inflammatory cytokines in all observation times. © 2015 Asian Pacific Tropical Medicine Press.
Medical Faculty, University of Brawijaya, Malang, East Java, Indonesia
