Kusuma Andriana, Halida Nelasari, I. Wayan Arsana W.
Background: Changes in fat metabolism by estrogen deficiency is one of the factors increasing the risk of CHD in postmenopausal women. Black cumin (Nigella sativa) is a spice that can be used as a medicinal plant. From several studies, Nigella sativa could show the effects of estrogen. Objective: to determine the effect of black cumin (Nigella sativa) against changes on LDL/HDL ratio of the ovariectomized white mouse (Rattus novergicus wistar strain) Method: True Experimental design with the post test only control group design with 25 female mouse divided into five groups: 2 controle group positive and negative, and 3 treatment groups of black cumin extract at a dose of 1.25, 2.5 and 5 mg/kg BW /day. Results: One way ANOVA test showed the non significant value (p > 0.05) of weight changes (p: 0.055), HDL level (p: 0.326) and LDL level ( p: 0.659). At Kruskal-Wallis test showed the non significant value of LDL/HDL ratio (p: 0.152 (p > 0.05)). Conclusion: Extract of black cumin (N. sativa) could not significant affect on LDL/HDL ratio of the ovariectomized white mouse (Rattus novergicus wistar strain). © 2015 AENSI Publisher All rights reserved.
University of Brawijaya Malang, Indonesia; University of Muhammadiyah Malang, Indonesia; Departement of Obstetric and Gyneology, University of Muhammadiyah Malang Hospital, Indonesia; Departement of Obstetric and Gyneology, Saiful Anwar Hospital, University of Brawijaya Malang, Indonesia
