Djanggan Sargowo, W. Titin Andri, Teuku Heriansyah, Indra Prasetya, Ria Ashriyah, Ira Setyawati
This study was aimed to evaluate anti-inflammatory and antioxidant effect of polysaccharide peptide (PsP) from Ganoderma lucidum in atherosclerosis. The atherosclerotic rats were randomly divided into four groups (5 rats each group): atherosclerotic model with high-fat diet, low dose PsP treated group (50 mg/kgBW), medium dose PsP treated group (150 mg/kgBW), high dose PsP treated group (300 mg/kgBW), with normal mice used as a control group. Parameters measured were the level of MDA, SOD, IL - 6, IL - 10, hsCRP, TNF - á, lipid profile and foam cell. After PsP therapy for 5 weeks, the levels of MDA (p=0.01), hsCRP (p=0.018) in rats model of atherosclerosis decrease significantly. PsP can reduce levels of IL - 6 (p=0.933) and increase levels of SOD (p=0.28) descriptively at PsP doses 150 mg/kgBW. While the levels of TNF-á (p=0.894) and IL-10 (p=0.98) was not affected by administration of PsP. PsP improve the lipid profile by increasing HDL (p=0.002) and lowering total cholesterol (p=0.04). The formation of foam cells (p=0.024) as a marker of atherogenesis significantly decreased by administration of PsP. PSP can be useful to reduce inflammatory processes and oxidative stress to prevent atherogenesis.
Department of Cardiology and Vascular Medicine, Faculty of Medicine, Brawijaya University, Dr. Saiful Anwar Hospital, Malang, Indonesia; Department of Nursery, Faculty of Medicine, Brawijaya University, Malang, Indonesia; Department of Cardiology and Vascular Medicine, Faculty of Medicine, Syiah Kuala University, Dr. Zainoel Abidin Hospital, Banda Aceh, Indonesia; Department of Internal Medicine, Faculty of Medicine, Brawijaya University, Dr. Saiful Anwar Hospital, Malang, Indonesia
