Alvan F. Shalas, Siswandono, Marcellino Rudyanto
Objective: The research was aimed to synthesize 1-allyl-3-(2-chlorobenzoyl) thiourea and determine its analgesic activity in mice (Mus musculus). Methods: The synthesis was carried out by modified Schotten-Baumann reaction, via nucleophilic substitution reaction of allylthiourea on 2-chlorobenzoyl chloride. The analgesic test was done by writhing test on mice (Mus musculus). Results: Pure 1-allyl-3-(2-chlorobenzoyl) thiourea was obtained, confirmed by means of UV, IR,1H-NMR,13C-NMR, and MS spectroscopy. The compound showed better pain inhibition activity compared to diclofenac sodium, with ED50 = 15.440 mg/kg BW. Conclusion: The compound 1-allyl-3-(2-chlorobenzoyl) thiourea can be synthesized by one-step modified Schotten-Baumann reaction, and showed a good analgesic activity. The compound needs further investigation as a potential analgesic drug candidate. © 2016 The Authors.
School of Pharmacy, Medical Faculty, Brawijaya University, Malang, East Java, Indonesia; Faculty of Pharmacy, Airlangga University, Surabaya, 60286, East Java, Indonesia
