W. Khoirunnisa, S. Puspitarini, S.A. Rohmawati, F. Eltavia, R.P. Rahayu, D.H. Utomo, G.W. Permatasari
Background: Formaldehyde (H2C=O) is a flammable, colourless reactive compound and readily polymerized gas at normal pressure and room temperature with a relative molecular mass of 30.03 and a pungent odour. Methodology: Formaldehyde in aqueous solution enters the bloodstream directly. These events are most likely occur in dialysis or in surgery with assisted circulation, which is the dialysis machine and tubes are disinfected with formaldehyde. Results: It is observed that proteins (DHRS4, AOC3, ALDH3A1, ADH5, FOS, TRPA1, DMGDH, SARDH, PIPOX and SHMT2) that interacted with formaldehyde compound out of which the fructooligosaccharide (FOS) is protein that work in cancer case. The STITCH method was used to analyse interaction between formaldehyde and protein, STRING for analyse protein interaction and KEGG pathway to generate the pathway of molecular mechanism in cell. Conclusion: The FOS have role in response to calcium ion, if the formaldehyde bind with fructooligosaccharide, it will be doubt the homeostasis of altered Ca2+, cation and ion channel activity. © 2016 W. Khoirunnisa et al.
Laboratory of Computational Biology, Department of Biology, University of Brawijaya, Indonesia
