Aulanni’am Aulanni’am, Agung Praman W. Marhendra, Dyah Kinasih Wuragil
Smoking, either active or passive was widely demonstrated inflamed respiratory organs through changing ratio oxidant anti-oxidant that causes inflammation. Herbal-based antioxidant therapy reduces inflammatory process, but the mechanism is still unclear. This study mainly aims the potencyof manggosteen peel extract to normalize the oxidant-antioxidant ratio and repair functional structure of epithelial bronchi on cigarette smoke induced rats. This study used cigarette smoke induced rats (Rattus norvegicus) 3-month-old male were divided into 5 groups. Group 1 was healthy rats (negative control group), group 2 was cigarette smoke induced rats (positive control group); groups 3, 4 and 5 (theraphy groups) were cigarette smoke induced rats also administered with mangosteen peel extract (Garcinia mangostana L) with dose of 150 mg / kg BW, 300 mg / kg BW, and 600 mg / kg BW, respectively. Inflammation was observed by epithelial histopathology structure of bronchioles and the level of oxidant antioxidant measured based on MDA level and SOD activity using spectrophotometry. The results showed that the extract of mangosteen peel (Garcinia mangostana L) significantly reduced the levels of MDA (p <0.05) and increased the SOD activity. The extract of mangosteen peel (Garcinia mangostana L) was able to improve epithelial histopathology structure of bronchi on cigarette smoke induced rats. We concluded that the extract of mangosteen peel (Garcinia mangostana L) could reduce the levels of MDA, increase SOD activity and repair damaging of bronchial tissue. © 2015, Sphinx Knowledge House. All rights reserved.
Biochemistry Laboratory, Brawijaya University, Indonesia; Veterinary Medicine School, Brawijaya University, Indonesia; Biology Department, Brawijaya University, Indonesia
