Dwi Kartika Risfianty, Chanif Mahdi, Dyah Kinasih Wuragil, Aulanni’Am Aulanni’Am
Black soybean’s (Glycine max (L.) Merr) is a tropical plant and spread widely in Southeast Asia including Indonesia. It contains of black soybean’s are rich in fiber but has not been widely used for the treatment of cholesterol. This paper discusses recent investigation on the benefits of dietary fiber black soybean’s decrease the MDA levels on high cholesterol diet induced rats. Twenty wistar male rats (Rattus norvegicus) divided into 4 groups. The first group was negative control. The second group was hypercholesterolemic rats induced with hyprcholesterolemic diet consisted of 10% lard, cholic acid, and a quail egg yolk which has been heated (100°C) mixed with corn oil to 2 ml as well as standard feed for 2 weeks. The third and fourth groups of rats were therapied with dietary fiber of black soybean dose of 0.72g/kgWB and 1.44g/kgWB, respectively. The result showed dietary fiber theraphy decreasing of MDA levels of hypercholesterolemic rats to be 38.198% and 48.922% at dose of 0.72g/kgWB and 1.44g/kgWB, respectively. Statistical analysis showed that each treatment group were significantly different (p<0.05). It also could repair hepar tissue which showed by decreasing of fat accumulation on hepatocyte. The conclusion from this study was dietary fiber of black soybean had potentialy as an alternative treatment of hypercholesterolemia. © 2016, International Journal of Pharmaceutical and Clinical Research. All rights reserved.
Department of Chemistry, Faculty of Sciences, Brawijaya University, Indonesia; Faculty of Veterinary Medicine, Brawijaya University, Indonesia
