Sylvi Wafda Nur Amellia, Yuyun Yueniwati, Sutrisno Sutrisno
This study aimed to investigate whether the genistein is able to decrease the expressions of vascular endothelial growth factor-A (VEGF-A) and hypoxia inducible factor-1α (HIF-1α) in mouse model of endometriosis. Forty female mice (Mus musculus) were divided into eight groups (n = 5 each), including the control (untreated) group, endometriosis group, and endometriosis groups treated with various doses of genistein (50; 100; 200; 300; 400; and 500 mg/day). VEGF-A and HIF-1α analyses were performed by immunohistochemistry. We found significant increases in the VEGF-A and HIF-α expressions in endometriosis group compared to the control group. The increased expressions of VEGF-A and HIF-1α were significantly (p < 0.05) attenuated by the administration of all doses of genistein. In conclusion, in mouse model of endometriosis, genistein potentially inhibits the increase in angiogenesis in peritoneal tissue. Therefore, this result may provide a novel anti-angiogenic treatment strategy for the therapy of endometriosis. © 2016 Middle East Fertility Society
Midwifery Master Study Programme, Faculty of Medicine, Brawijaya University, Malang, East Java, Indonesia; Department of Radiology, Saiful Anwar General Hospital, Faculty of Medicine, Brawijaya University, Malang, East Java, Indonesia; Division of Fertility, Endocrinology and Reproduction, Department of Obstetric and Ginaecology, Saiful Anwar General Hospital, Faculty of Medicine, Brawijaya University, Malang, East Java, Indonesia
