Hamny Hamny, Muhammad Jalaluddin, Siti Aisyah, Sri Wahyuni, Widodo, Aulanni’am Aulanni’am
Follicle stimulating hormone (FSH) bond with the extracellular domain of the FSH receptor (FSHR) stimulates a cascade of the intracellular process that leads to folliculogenesis. This study aimed to elucidate the effects of FSHR polymorphism of its structure and function on Bos taurus through computational technology. The FSHR sequences were retrieved from Genebank. The polymorphism was identified using alignment analysis and the 3D structure of the FSHR was done by Swiss models. Results showed that FSHR of Bos taurus has three polymorphisms that located at amino acid residues 18th to 259th. The polymorphisms may alter its ability to bind with FSH. Molecular docking analysis indicated that all variant of FSHR potentially changes the pattern and affinity binding into FSH that may have an impact on reproduction status of Bos taurus. The study is a warrant for further investigation to explore biomarker of cattle reproduction status based on FSHR gene. © 2017, Agricultural Research Communication Centre. All rights reserved.
Laboratory of Anatomy, Faculty of Veterinary Medicine, Syiah Kuala University, Banda Aceh, Indonesia; Biology Department, Faculty of Mathematics and Natural Sciences, Brawijaya University, Malang, East Java, Indonesia; Department of Biochemistry, Brawijaya University, Malang, East Java, Indonesia; Aging Research Institute, Brawijaya University, Malang, East Java, Indonesia
