Wahyu Widowati, Omat Rachmat, Tri Suciati, Dwi Davidson Rihibiha, Ervi Afifah, Tjandrawati Mozef, Rizal Rizal, Teresa Liliana Wargasetia, Sutiman B. Sumitro
Osteoarthritis is commonly the most joint disorder that rises with the aging of the population. The oxidative stress and overproduction of reactive oxygen species (ROS) are responsible for many process related to osteoarthritis such as the intracellular signaling process, apoptosis, extracellular matrix synthesis, dysfunction of the subchondral bone, and other processes. Thus far, drugs for osteoarthritis are still scarce, therefore targeting the complex oxidative stress signaling pathways would be a potential strategy in finding treatment of this disease. © 2018 Nova Science Publishers, Inc. All rights reserved.
Faculty of Medicine, Maranatha Christian University, Bandung, West Java, Indonesia; Department of Orthopaedic Surgery, Dradjat Prawinegara Hospital, Serang, Banten, Indonesia; School of Pharmacy, Bandung Institute of Technology, Bandung, West Java, Indonesia; Aretha Medika Utama, Biomolecular and Biomedical Research Centre, Bandung, West Java, Indonesia; Research Centre of Chemistry, Indonesian Institute of Sciences, Serpong, Banten, Indonesia; Department of Biology, Faculty of Mathematics and Natural Science, Brawijaya University, Malang, East Java, Indonesia
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