Atma Gunawan, Kusworini Handono, Handono Kalim, Hani Susianti, Mudjiwijono Handaru Eko, Gatot S. Lawrence, Dian Hasanah, Etik Mertianti, Didi Candradikusuma
Introduction: Our aim was to re-evaluate the roles of HLA-DRB1 alleles on susceptibility, severity, activity and chronicity index of lupus erythematosus nephritis in Indonesia. Materials and Methods: A total of 55 lupus nephritis patients and 52 healthy subjects as control were analyzed. HLA-DRB1 alleles examination was performed using polymerase chain reaction (PCR) followed by electrophoresis. Differences in HLA-DRB1 allele frequencies between lupus nephritis group and healthy group, between mild and severe lupus nephritis, and between high and low activity and chronicity index were analysed using Chi-square test, presented as odds ratio (OR). Results were considered significant at P value less than 0.05. Results: HLA-DRB1*1501 was a susceptible allele for lupus nephritis group (OR=3.18; p=0.010). HLA-DRB1*1501 was also a susceptible allele for high activity index (OR=7.4; p=0.006). Although not statistically significant, HLA-DRB1*1501 was a susceptible allele for high chronicity index (OR=3.2; p=0.07). We found HLA-DRB1*0401 was a protective allele against severe class of lupus nephritis (OR=9.4; p=0.029). Conclusion: HLA-DRB1*1501 was a susceptible allele for lupus erythematosus nephritis with high activity and chronicity index. HLA-DRB1*0401 was a protective allele against severe class of lupus nephritis. © 2018 Turkish Journal of Immunology. All rights reserved.
Nephrology Division of Internal Medicine Department in Dr. Saiful Anwar General Hospital, Malang, Indonesia; Clinical Pathology Department of Dr. Saiful Anwar General Hospital, Malang, Indonesia; Rheumatology Division of Internal Medicine Department in Dr. Saiful Anwar General Hospital, Malang, Indonesia; Pathology Departement in Dr. Saiful Anwar General Hospital, Malang, Indonesia; Pathology and Forensic Departement in Universitas Hasanuddin, Makassar, Indonesia; Physiology Department in Universitas Brawijaya, Malang, Indonesia; Internal Medicine Department in Universitas Brawijaya Hospital, Malang, Indonesia; Tropical Diseases and infections Division of Internal Medicine in Dr. Saiful Anwar General Hospital, Malang, Indonesia
