Yusuf Wibisono, Eka Tiyas Anggraeni, Dikianur Alvianto, Susi Rokhmatul Ummah, Dede Heri Yuli Yanto, Tonni Agustiono Kurniawan, Husnul Azan Tajarudin, Wahyunanto Agung Nugroho
Agricultural waste, particularly lignocellulosic and agro-industrial by-products, is abundant in developing countries and represents a valuable resource for biotechnological applications. Among biobased chemicals, bio-succinic acid (BSA) has emerged as a key platform chemical with broad industrial relevance, including in biodegradable plastics, agriculture, and pharmaceuticals. This review explores BSA production from underutilized agricultural residues through microbial fermentation using bacteria and yeast. A bibliographic analysis of 3569 publications (1988–2023) is conducted to highlight advances in biological synthesis, fermentation strategies, and bioreactor operations. Key microbial strains discussed include Actinobacillus succinogenes, Basfia succiniciproducens, and Saccharomyces cerevisiae. Feedstocks such as corn stover, cane molasses, and glycerol are evaluated for their process viability. Challenges in downstream processing and product purification are critically examined. The review proposes future directions, including metabolic engineering, synthetic biology, and membrane-based purification systems, for scalable and sustainable BSA production. By valorizing organic waste, this process supports circular economy principles and offers economic and environmental co-benefits. © 2025 Elsevier Ltd
Department of Bioprocess Engineering, Faculty of Agricultural Technology, Universitas Brawijaya, Malang, 65141, Indonesia; Department of Agricultural Engineering, Faculty of Agricultural Technology, Universitas Jember, Jember, 68121, Indonesia; Department of Agricultural Product Technology, Faculty of Agriculture, Universitas Mulawarman, Samarinda, 75119, Indonesia; Department of Agricultural and Biosystems Engineering, Faculty of Agricultural Technology, Brawijaya University, Malang, 65141, Indonesia; Research Center for Applied Microbiology, National Research and Innovation Agency (BRIN), Cibinong, 16911, Indonesia; College of the Environment and Ecology, Xiamen University, Fujian, Xiamen, 361102, China; School of Industrial Technology, Universiti Sains Malaysia, Pulau Pinang, 11800 USM, Malaysia; MILI Institute for Water Research, Kawasan Industri Jababeka, Cikarang Utara, Bekasi, 17530, Indonesia
