Wahyu Widowati, Rachmawati Noverina, Wireni Ayuningtyas, Dedy Kurniawan, Ahmad Faried, Dian Ratih Laksmitawati, Dwi Davidson Rihibiha, Rizal Rizal, Tri Suciati, Sutiman B. Sumitro
Skin aging is a complex process affected by both genetic and environmental factors, and it is caused by the cumulative damage from exposure to ultraviolet (UV) radiation. Chronic exposure to UV radiation on human skin further generates solar elastosis, degradation of the extracellular matrix (ECM), and wrinkle formation. UV radiation exposure leads to production of reactive oxygen species (ROS) in the skin. Chronological & photo-aging occurred via ROS by cascade signaling pathways. Treatment of antioxidants is an effective approach to prevent symptoms related to photo-induced skin aging. In this chapter, the mechanisms of ROS generation in the skin, the roles of ROS in altering the skin and ROS elimination in the body are discussed. © 2018 Nova Science Publishers, Inc. All rights reserved.
Faculty of Medicine, Maranatha Christian University, Bandung, West Java, Indonesia; Laboratory of Animal and Stem Cells, PT Bio Farma (Persero), Bandung, West Java, Indonesia; Neurosurgery Department, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia; Faculty of Pharmacy, University of Pancasila, Jakarta, Indonesia; Aretha Medika Utama, Biomolecular and Biomedical Research Centre, Bandung, West Java, Indonesia; School of Pharmacy, Bandung Institute of Technology, Bandung, West Java, Indonesia; Department of Biology, Faculty of Mathematics and Natural Sciences, Brawijaya University, Malang, East Java, Indonesia
