Hariwati Moehariadi, Fariz Nufiarwan, Lely Retno Wulandari, Hidayat Sujuti
Background To determine the effects of mangosteen (Garcinia mangostana) pericarp extracts on retinoblastoma cell culture proliferation. Methods This study was a true experimental in vitro design with a pre- and post-test control group. Retinoblastoma cell cultures were exposed to mangosteen pericarp extract (Garcinia mangostana) at doses of 10 μg/ml, 20 μg/ml, and 40 μg/ml. Results The retinoblastoma cell line cultures were obtained from the American Type Culture Collection (ATCC). The samples were divided into four groups: A control group and three groups treated with 10 μg/ml, 20 μg/ml, and 40 μg/ml, respectively, of mangosteen pericarp extract. The samples were then incubated for 48 hours and examined using an MTT cell proliferation assay. Group 1 (10 μg/ml) showed a decrease of 151.8%, group 2 (20 μg/ml) showed a decrease of 134.6%, and group 3 (40 μg/ml) showed a decrease of 134.36%. Conclusion Mangosteen pericarp extract (Garcinia mangostana) can reduce retinoblastoma culture cell proliferation. © 2018 Wolters Kluwer Medknow Publications. All rights reserved.
Department of Ophthalmology, Faculty of Medicine, Brawijaya University, Malang, 65145, Indonesia
