A.Y.P. Wardoyo, U.P. Juswono, J.A.E. Noor
Many epidemiological studies, whether in vivo or in vitro in human or mammals indicate that particulate matters emitted by diesel vehicles have impacts on health. While the effects of daily particulate matter exposure have been well reviewed, the physiological evidence of mice blood alteration associated with the exposure to the diesel exhaust particles has not been investigated well. In this study, we examined the association between the exposure to ultrafine particles contained in the diesel exhaust emission and mice erythrocyte deformation. Ultrafine particles (diameter: 0.02 µm to 0.10 µm) were filtered from three different diesel engine cars. There were 50 male mice used as the experimental animals. The mice were exposed to the ultrafine particles in the different concentration for eight consecutive days. The total concentration of ultrafine particles was measured using a P-Trak Ultrafine Particle Counter (TSI, Model 8525). The mice were sacrificed after the eight-day exposures. The blood samples were observed using a Binocular BX-51 Computer Microscope to examine the level of erythrocyte deformation. The results showed that the increasing amount of the ultrafine particle concentrations caused the increasing extent of the erythrocytes deformation level significantly. © 2018, ALÖKI Kft., Budapest, Hungary.
Laboratory of Air Quality and Astro Imaging, Department of Physics, Brawijaya University, Jl. Veteran, Malang, 65145, East Java, Indonesia
