E. Martati, M.A. Akmalina
Fennel (Foeniculum vulgare Mill.) has been used as traditional medicines, although conversely, it also contains genotoxic and carcinogenic compounds an alkenylbenzene of estragole. Therefore, fennel should be a health risk evaluation. The aims of this study were to analyze the total phenolic content (TPC), total flavonoid (TFC) and the concentration of alkenylbenzene of estragole in ethanolic and methanolic extract of fennel (Foeniculum vulgare Mill.). Furthermore, the concentration of estragole in the extract was used to make relation between intakes of extract and the resulted Margin of Exposure (MOEs). The results showed that TPC, TFC and capacity of antioxidant of methanolic extract of fennel were higher than that of ethanolic extract. In simulation, the intake of methanolic and ethanolic extracts of fennel which were > 168-331 and > 49-97 mg/60 kg bw per day for life time, respectively, resulted a MOE < 10,000. Therefore, it was considered as a high priority for risk management actions and would be of high concern from a public health point of view. © All Rights Reserved.
Study Program of Food Science and Technology, Department of Agricultural Product Processing, Universitas Brawijaya, Jalan Veteran, Malang, 64145, Indonesia
