W. Warsito, A.S. Noorhamdani, Suratmo, R Dwi Sapri, D. Alkaroma, A.Z. Azhar
Simple method has been used for the synthesis of benzimidazole derivative from citronellal in kaffir lime oil under microwave irradiation. These compounds were synthesized also by conventional heating for comparison. In addtion, microwave-assited synthesis was also compared between using to dichloromethane and methanol solvents with variation of reaction time for 30 to 70 minutes and 4 to 12 h for conventional heating. The 2-citronellyl benzimidazole compound synthesized were characterised by FT-IR, GC-MS, 1H and 13C NMR spectroscopy. Comparison between conventional and microwave-assisted synthesis was done by comparing between correlation of reaction time and percentage yield. The time optimum of microwave-assisted and conventional synthesis using dichloromethane solvent respectively at 60 minutes (yield 19.23%) and 8 hours (yield 11.54%). In addition, microwave-assited synthesis increasing 157.81 times compared by conventional heating. While using methanol solvent tends to increase linearly however the percentage of yield only 0.77 times of synthesis using dichloromethane solvent. © 2018 Institute of Physics Publishing. All rights reserved.
Department of Chemistry, Faculty of Science, Brawijaya University, Jl Veteran Malang, 65145, Indonesia; Essential Oil's Institute, Brawijaya University, Jl Veteran Malang, 65145, Indonesia; Department of Medical Faculty, Brawijaya University, Jl Veteran Malang, 65145, Indonesia
