L.B. Harti, S. Suprihati, T.N. Kristina
This research aimed to investigate whether Virgin Coconut Oil (VCO) can be effective to reduce the level of lectin-like oxidized LDL receptor 1 (LOX-1) and Lipoprotein-Associated phospholipase A2 (Lp-PLA2) as atherosclerotic biomarker. Thirty Wistar rats were categorized into 5 treatment groups; normal diet (ND), high-fat diet (HFD), HFD with 3 different dosages of VCO consecutively 1 ml, 1.2 ml, and 2 ml per day. The average levels of LOX-1 in three groups of HFD with VCO were significantly lower compared to HFD group (p=0.002, p=0.009, and p=0.038 respectively). The average levels of Lp-PLA2 in three groups of HFD with VCO were also shown to be lower than that of HFD group. However, the differences among these groups were not significant (p=0.93). The treatment of VCO with a dosage of 1.2 ml was significantly effective to reduce the level of LOX-1. Eventhough not statistically significant, VCO could also reduce the level of Lp-PLA2. © All Rights Reserved.
Nutritional Science Program Faculty of Medicine, Brawijaya University, Malang, East Java, 65145, Indonesia; Faculty of Medicine, Diponegoro University, Semarang, Central Java, 50275, Indonesia
