Latifah Fitriani Rahman, Octaviana Widya Pangestika, Delvi Fitriani, Rudhanton Rudhanton, Nur Permatasari
Objective: The study examined the effects of Aloe vera ethanol extract on alveolar mandible regeneration in rats (Rattus norvegicus). Methods: Rats were divided into five groups as follows: Negative control group received no treatment, positive control group received Escherichia coli lipopolysaccharide (LPS) alone for 5 days, and Groups P1, P2, and P3 received LPS for 5 days followed by 40, 80, and 160 mg/kg BW A. vera ethanol extract, respectively, orally on days 6-12. Alveolar bone tissues were taken and histologically processed through hematoxylin-eosin staining. Osteoblast and osteoclast numbers in alveolar tissue were also examined. Results: One-way ANOVA revealed strong relationships between the A. vera ethanol extract dosage and the numbers of osteoblasts (r=0.921, p<0.05) and osteoclasts (r=-0.631, p<0.05) in rats. Conclusion: A. vera ethanol extract appears capable of stimulating alveolar bone regeneration following LPS exposure. © 2018 The Authors. Published by Innovare Academic Sciences Pvt Ltd.
Department of Academic, Faculty of Dentistry, University of Brawijaya, Malang, 65145, Indonesia; Department of Periodontia, Faculty of Dentistry, University of Brawijaya, Malang, 65145, Indonesia; Department of Oral Biology, Faculty of Dentistry, University of Brawijaya, Malang, 65145, Indonesia
